Pramipexole

Product Details – Pramipexole

Pramipexole is a non-ergot dopamine agonist belonging to the benzothiazole class of compounds. In experimental models, pramipexole is primarily used as a selective agonist of dopamine D2-like receptors, making it a valuable compound in in vitro studies focused on neurotransmitter-receptor interactions and signal transduction mechanisms.

Mechanism of Action

Pramipexole exhibits high affinity for dopamine D2-like receptor subtypes, particularly D2 and D3 receptors. Upon binding, it activates G protein-coupled receptor (GPCR) signaling pathways, leading to inhibition of adenylate cyclase activity and modulation of intracellular cyclic AMP (cAMP) levels.

In preclinical models, this receptor activation influences downstream signaling cascades, including regulation of ion channel activity and phosphorylation pathways. Pramipexole demonstrates preferential binding to D3 receptors in research models, enabling targeted investigation of receptor subtype-specific signaling and functional selectivity.

Its activity provides a framework for studying dopaminergic neurotransmission and receptor-mediated cellular responses in controlled laboratory environments.

Properties

• Molecular Formula: C10H17N3S
• Molecular Weight: 211.32 g/mol
• CAS Number: 104632-26-0
• PubChem CID: 119570
• Synonyms: Mirapex, Mirapexin, Sifrol, Pramipex, Pexola

Research Applications

Applications in in vitro and experimental models include:

• Investigation of dopamine D2/D3 receptor binding affinity and selectivity
• Analysis of GPCR-mediated signal transduction pathways
• Study of intracellular cAMP modulation and downstream signaling effects
• Evaluation of receptor subtype-specific activity in dopaminergic systems
• Use as a reference compound in comparative studies of dopamine agonists in preclinical models

Its receptor selectivity and well-characterized pharmacological profile make pramipexole a valuable tool for mechanistic studies of dopamine-mediated cellular processes.

Why Choose BehemothLabz to Buy Pramipexole

Choose BehemothLabz for research-focused quality and consistency. Our Pramipexole are manufactured to meet rigorous standards suitable for laboratory and experimental use.

Each batch undergoes third-party testing to verify purity, composition, and consistency. This ensures that researchers receive a product aligned with strict analytical requirements.

We offer secure ordering systems and reliable shipping options for both domestic and international customers. Our processes are designed to maintain confidentiality and protect customer data at every stage.

With BehemothLabz, you are selecting a product developed to support precision and reliability in research environments.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments. 

References:

• Montplaisir, J., Nicolas, A., Denesle, R., & Gomez-Mancilla, B. (1999). Restless legs syndrome improved by pramipexole. Neurology, 52(5), 938. https://doi.org/10.1212/wnl.52.5.938
• Barone, P., Poewe, W., Albrecht, S., Debieuvre, C., Massey, D., Rascol, O., Tolosa, E., & Weintraub, D. (2010). Pramipexole for the treatment of depressive symptoms in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled trial. The Lancet Neurology, 9(6), 573–580. https://doi.org/10.1016/s1474-4422(10)70106-x