Myo-Inositol Trispyrophosphate (ITPP) Capsules

Buy ITPP Capsules

Buy ITPP Capsules from behemothlabz for laboratory research. Review the exact product identity and listed format before choosing this material for your work.

Product selection

Listed variant options:

• 100mg per capsule / 30ct / 3000mg
• 100mg per capsule / 60ct / 6000mg
• 50mg per capsule / 30ct / 1500mg
• 50mg per capsule / 60ct / 3000mg

Select the exact option to see its current price and availability. Quantities and concentrations describe the listing and are not use instructions.

Mechanism of Action

ITPP interacts with hemoglobin within erythrocytes, modulating its oxygen-binding affinity. In research models, this interaction stabilizes the deoxygenated (T-state) conformation of hemoglobin, thereby shifting the oxygen dissociation curve and facilitating increased oxygen release under controlled conditions.

In preclinical models, ITPP is observed to penetrate red blood cells and alter intracellular biochemical conditions, influencing hemoglobin-oxygen equilibrium. This modulation provides a framework for studying oxygen transport efficiency, hypoxia-related signaling pathways, and cellular adaptation to reduced oxygen availability in experimental systems.

Properties

• Molecular Formula: C6H12O21P6
• Molecular Weight: 605.99 g/mol 
• CAS Number: 802590-64-3
• Synonyms: Myo-inositol trispyrophosphate, ITPP, 116EYZ0PPX, DTXCID301514847, DTXSID301029636

Research Applications

Applications in in vitro and experimental models include:

• Investigation of hemoglobin oxygen-binding dynamics and dissociation kinetics
• Study of oxygen delivery mechanisms at the cellular and molecular level
• Analysis of hypoxia-inducible factor (HIF) pathway regulation under controlled oxygen conditions
• Exploration of tumor microenvironment models with altered oxygen gradients in preclinical systems
• Evaluation of erythrocyte-mediated oxygen transport in biochemical and physiological research models

Its ability to modulate hemoglobin-oxygen interactions makes ITPP a valuable compound for mechanistic studies involving oxygen availability and hypoxia-related signaling pathways.

References:

• Gorgens, C., Guddat, S., Schanzer, W., & Thevis, M. (2014). Screening and confirmation of myo‐inositol trispyrophosphate (ITPP) in human urine by hydrophilic interaction liquid chromatography high resolution / high accuracy mass spectrometry for doping control purposes. Drug Testing and Analysis, 6(11–12), 1102–1107. https://doi.org/10.1002/dta.1700
• Krzykawska-Serda, M., Szczygiel, D., Gaweł, S., Drzal, A., Szczygiel, M., Kmieć, M. M., Mackiewicz, A., Kieda, C., & Elas, M. (2023). Oxygen therapeutic window induced by myo-inositol trispyrophosphate (ITPP)–Local pO2 study in murine tumors. PLoS ONE, 18(5), e0285318. https://doi.org/10.1371/journal.pone.0285318
• Sihn, G., Walter, T., Klein, J., Queguiner, I., Iwao, H., Nicolau, C., Lehn, J., Corvol, P., & Gasc, J. (2007). Anti‐angiogenic properties of myo‐inositol trispyrophosphate in ovo and growth reduction of implanted glioma. FEBS Letters, 581(5), 962–966. https://doi.org/10.1016/j.febslet.2007.01.079

Documentation for laboratory purchasing

For batch-dependent specifications, request the report associated with the material you will receive. Match the product identity, lot number and test date to your records. Review the relevant safety data and laboratory requirements before handling the material.

Ordering questions

Which ITPP Capsules option should I select?

Choose the exact listed quantity or configuration required by your laboratory. For blends, confirm the amount of each component rather than assuming the total is a per-component amount.

What documentation should I check?

Check the batch identity and the analytical evidence relevant to your requirements. A general product description does not replace a report for the supplied lot.

Is this intended for personal use?

No. This product is offered for laboratory research only and is not for human or veterinary use.

Related research products

• Myo-Inositol Trispyrophosphate (ITPP) Liquid
• The Atlantis Stack (ITPP + GW-0742 + SR-9011)

These links are provided for catalog comparison. They are not recommendations to combine or administer products.

Browse the Capsules category for more listings.

For laboratory research only. Not for human or veterinary use.