Buy MK-777 Acetamoren
Buy MK-777 Acetamoren from behemothlabz for laboratory research. Review the exact product identity and listed format before choosing this material for your work.
Product selection
Listed form , strength options:
- Capsule, 20mg / 30ct / 600mg
- Capsule, 20mg / 60ct / 1.2g
- Liquid, 30ml / 33mg per ml / 1000mg
- Liquid, 30ml / 67mg per ml / 2000mg
Select the exact option to see its current price and availability. Quantities and concentrations describe the listing and are not use instructions.
What is MK-777 (Acetamoren)?
MK-777 is also identified by the chemical name Acetamoren. It is a non-peptide small molecule. It is currently under early-stage preclinical investigation as a ligand for the growth hormone secretagogue receptor, GHS-R1a (the ghrelin receptor). In laboratory research, it is studied for in vitro receptor binding investigation and preclinical ghrelin-pathway research.
In laboratory research models, MK-777 is studied for its interaction with key neuroendocrine pathways, including:
- Ghrelin receptor (GHS-R1a) binding and selectivity
- Growth hormone (GH) and IGF-1 axis signaling
- Hypothalamic and pituitary receptor activation in preclinical research models
Note: As of 2026, MK-777 has not been the subject of a peer-reviewed clinical or preclinical publication.
ATTENTION: This product is strictly for LABORATORY AND RESEARCH PURPOSES ONLY. Not for human or veterinary use.
Mechanism of Action of MK-777 (Acetamoren)
Ghrelin Receptor (GHS-R1a) Binding Research:
MK-777 is under investigation in in vitro receptor binding assays as a non-peptide ligand at the growth hormone secretagogue receptor (GHS-R1a). Preclinical receptor-binding assay development and comparative pharmacology against the parent compound class (ibutamoren/MK-677, spiropiperidine GHS-R1a agonists) are the primary research contexts.
Comparative Non-Peptide GHS-R1a Pharmacology:
MK-777 is used in laboratory research as a reference compound within the non-peptide spiropiperidine GHS-R1a agonist family. This enables a structure-activity relationship investigation and binding-kinetics research in cell-free and cell-culture assay systems.
Chemical Properties of MK-777 (Acetamoren)
- Molecular Formula: C₂₉H₃₈N₄O₆S
- Molecular Weight: 570.7 g/mol
- CAS Number: 950841-87-9
- Synonyms: Acetamoren, MK777, MK 777
- IUPAC Name: Propanamide, 2-(acetylamino)-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4′-piperidin]-1′-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-
- Physical Form: White to off-white crystalline powder
- Solubility: Soluble in DMSO; limited aqueous solubility
- Classification: Research Use Only
The values above reflect the ChemicalBook reference entry for CAS 950841-87-9.
1. GHS-R1a Receptor Binding Assay Research
MK-777 is investigated in in vitro ghrelin receptor (GHS-R1a) binding assay characterization. In cell-free receptor preparation systems, it serves as a reference non-peptide ligand for binding kinetics and receptor occupancy studies.
2. Structure-Activity Relationship (SAR) Studies
As a member of the non-peptide spiropiperidine GHS-R1a agonist class, MK-777 is used in comparative SAR investigation alongside parent class compounds, including ibutamoren (MK-677).
- Preclinical Ghrelin Pathway Pharmacology
MK-777 is investigated in ghrelin receptor-transfected cell line systems for preclinical pharmacology research. It serves as a reference compound for competitive binding displacement assays in experimental settings.
4. Analytical Chemistry Method Development
MK-777 is used in analytical chemistry method development for the spiropiperidine chemical series. This includes HPLC retention time characterization and mass spectrometry confirmation against CAS 950841-87-9 reference data.
5. Comparative GHS-R1a Agonist Research
In laboratory settings, MK-777 is compared against other non-peptide GHS-R1a agonists to investigate receptor selectivity profiles and binding kinetics. Evidence remains mixed, and data are limited to in vitro experimental systems.
Risk & Handling
MK-777 is a CNS-active ghrelin receptor agonist under early-stage preclinical investigation. Researchers must observe the following precautions at all times.
Risk Tier: HIGH
This rating reflects the complete absence of toxicological data for MK-777, unknown receptor affinity and selectivity profile, potential bioactive effects on neuroendocrine pathways if GHS-R1a activity is confirmed, and elevated regulatory exposure associated with growth hormone secretagogue pathway compounds under the Anti-Drug Abuse Act of 1988. Researchers must observe the following precautions at all times.
Handling Precautions: MK-777 should be handled exclusively in a controlled laboratory environment by trained personnel. Avoid skin and eye contact. Use appropriate PPE, including gloves, a lab coat, and eye protection, when handling the compound. Work in a well-ventilated area or under a fume hood where possible.
Storage: Store lyophilized or powdered MK-777 at −20°C. Store in a dry, dark environment. Protect from light, heat, and moisture at all times. Avoid repeated freeze-thaw cycles.
Toxicity & Dependency Considerations: As a ghrelin receptor agonist, MK-777 mechanistically interacts with pathways involved in growth hormone regulation. The long-term toxicity profile of MK-777 in any biological system is entirely unknown. Data remains limited, and findings should not be extrapolated to human biology.
References:
Research Transparency Note: As of 2026, no peer-reviewed studies specific to MK-777 (Acetamoren) exist. The following references relate to the parent compound class (MK-677/ ibutamoren) and GHS-R1a pharmacology that provides investigational context for MK-777 research.
However, the following research/studies relate to the mechanism of the subject product:
- Howard, A. D., Feighner, S. D., Cully, D. F., et al. (1996). A receptor in the pituitary and hypothalamus that functions in growth hormone release. Science, 273(5277), 974–977. https://pubmed.ncbi.nlm.nih.gov/8688086/
- Hickey, G. J., Jacks, T. M., Schleim, K. D., et al. (1997). Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles. Endocrinology, 138(10), 4556–4561. https://pubmed.ncbi.nlm.nih.gov/9071975/
- Smith, R. G. (2005). Development of growth hormone secretagogues. Endocrine Reviews, 26(3), 346–360. https://pubmed.ncbi.nlm.nih.gov/15814847/
Documentation for laboratory purchasing
For batch-dependent specifications, request the report associated with the material you will receive. Match the product identity, lot number and test date to your records. Review the relevant safety data and laboratory requirements before handling the material.
Ordering questions
Which MK-777 Acetamoren option should I select?
Choose the exact listed quantity or configuration required by your laboratory. For blends, confirm the amount of each component rather than assuming the total is a per-component amount.
What documentation should I check?
Check the batch identity and the analytical evidence relevant to your requirements. A general product description does not replace a report for the supplied lot.
Is this intended for personal use?
No. This product is offered for laboratory research only and is not for human or veterinary use.
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For laboratory research only. Not for human or veterinary use.
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