Astressin B is a synthetic cyclic peptide consisting of a long-acting, non-selective antagonist of corticotropin-releasing factor (CRF) receptors. It stands for a structurally engineered analog of the CRF peptide family developed specifically for research use. Its formation involves systematic peptide analoging derived from the native CRF sequence isolated from hypothalamic and brain tissue models in preclinical settings.
Its potential application has made it a key investigational tool in neuroendocrine and gastrointestinal research. Some studies have found that it may interact with CRF receptor subtypes in various preclinical systems. A few of its potential roles may include stress pathway modulation and receptor binding research.
Astressin B is believed to interact with both CRFR1 and CRFR2 receptor subtypes. It functions as a competitive antagonist that displaces endogenous CRF ligands and related neuropeptides such as Urocortins at their binding sites.
How Does Astressin B Work?
Astressin B works by competitively blocking CRF receptor sites Rivier et al. (2013) . Some of its research-investigated mechanisms may include inhibition of CRF-induced adenylyl cyclase activation, suppression of downstream cAMP elevation, and modulation of HPA axis stress signaling.
Apart from that, it may also demonstrate gastrointestinal pathway involvement and act as a probe for dissecting peripheral versus central CRF receptor contributions in preclinical models.
Properties of Astressin B
| Property | Detail |
| Molecular Formula | C₁₈₃H₃₀₅N₄₇O₅₅ |
| Molecular Weight | 4043.7 g/mol |
| CAS Number | CAS Number: Refer to PubChem CID 73350132, ChemSpider 59008829, ChEMBL2370918 for confirmed compound identity |
| PubChem CID | 73350132 |
| Synonyms | Astressin-B, [D-Phe¹², Nle²¹·³⁸, C-α-MeLeu²⁷, Glu³⁰, Lys³³, C-α-MeLeu⁴⁰]-hCRF(9-41) |
| Type | Cyclic CRF Peptide Antagonist |
| Receptor Targets | CRFR1 and CRFR2 (non-selective) |
| Vial Size | 10mg |
| Form | Lyophilized Powder |
| Shelf Life | ≥24 months lyophilized under recommended conditions |
| WADA Status | Not listed on WADA 2026 Prohibited List. Verify via GlobalDRO.com prior to sport science research use. |
| Peptide Sequence | Key modifications: D-Phe¹², Nle²¹, Nle³⁸, C-α-MeLeu²⁷, Glu³⁰, Lys³³, C-α-MeLeu⁴⁰ relative to native hCRF(9-41) |
Research Findings on Astressin B
A study has focused on the role of Astressin B in CRF receptor antagonism and hair follicle cycle regulation. In experimental models involving CRF over-expressing mice displaying alopecia phenotypes, Astressin B has been shown to modulate hair follicle transition from the telogen to the anagen phase through peripheral CRF receptor blockade. PLOS ONE by Wang et al. (2011)
This process was associated with pigmentation restoration and maintained hair re-growth for over four months in controlled preclinical settings. These findings highlight its relevance in studying CRF receptor involvement in stress-related follicular biology and peripheral signaling pathways.
Research has also examined Astressin B’s effects on gastrointestinal motility during stress-induced gut signaling studies. Rivier et al. (2013) Studies have shown that Astressin B may suppress CRF-, urotensin I-, and sauvagine-induced delays in gastric emptying and alterations in colonic motility.
These effects were linked to its non-selective blockade at both CRFR1 and CRFR2 receptor subtypes, suggesting a role in regulating peripheral gut-brain stress axis signaling in experimental systems.
Note: Astressin B is not approved by the FDA for any medical use. It is intended strictly for laboratory research purposes only and is not for human consumption.
Why Choose to Buy Astressin B from BehemothLabz?
Researchers are recommended to buy Astressin B from reputable sources.
At BehemothLabz, you will find pure and high-quality Astressin B products for sale at affordable prices. Additionally, our delivery charges are very competitive, along with a fast shipping procedure. Fortunately, our delivery is available both at the national and international levels.
Most importantly, we have been supplying various peptides for years and have earned a reputable place in the vendors’ market.
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Reference Links
PubChem. (2024). Astressin B. Nih.gov; PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/73350132
Wang, L., Million, M., Rivier, J., Rivier, C., Craft, N., Stenzel-Poore, M. P., & Taché, Y. (2011). CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice. PLOS ONE, 6(2), e16377. https://pubmed.ncbi.nlm.nih.gov/21359208/
Rivier J, Gulyas J, Kirby D, Low W, Perrin MH, Kunitake K, DiGruccio M, Vaughan J, Reubi JC, Waser B, Koerber SC, Martinez V, Wang L, Taché Y, Vale W. Potent and Long-Acting Corticotropin Releasing Factor (CRF) Receptor 2 Selective Peptide Competitive Antagonists. Journal of Medicinal Chemistry. 2002;45(21):4737-4747. PMID: 12381951. https://doi.org/10.1021/jm0202122
Tache Y, Nozu T, Bernstein CN. CRF signaling pathways and gut dysmotility in stress models: Relevance for IBS. Current Gastroenterology Reports. 2010;12(4): 273-283. PMID: 20544287. https://pubmed.ncbi.nlm.nih.gov/20544287/
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