MOTS-C Nasal Spray

MOTS-C Nasal Spray delivers a lab-grade, 16-amino-acid mitochondrial-derived peptide (MDP) in a ready-to-use intranasal formulation. Naturally encoded within mitochondrial DNA, MOTS-C is among the most studied MDPs for its role in cellular energy regulation.

The nasal delivery route bypasses initial metabolic processing, enabling investigational delivery directly to target tissues — making this formulation a precise tool for preclinical and laboratory research models.

Molecular Profile

How It Works

MOTS-C is synthesized within mitochondria — the cell’s primary energy-producing organelles. In experimental models, the peptide translocates into cells and engages AMP-activated protein kinase (AMPK), a master metabolic sensor that modulates glucose and lipid metabolism to restore cellular energy balance under low-energy or stress conditions [1, 2].

Under energy-limited conditions, MOTS-C has been observed in preclinical studies to further translocate to the nucleus, where it interacts with transcriptional regulators governing genes tied to energy production and adaptive stress responses. These interactions influence glucose uptake, lipid processing, and energy storage — establishing MOTS-C as a mechanistically rich compound for studying metabolic adaptation at the molecular level [3, 4].

Why Choose Behemoth Labz

• Quality you can verify. Every batch of MOTS-C Nasal Spray is independently tested for purity and composition before it reaches your lab. We don’t just assert quality — we document it.
• Formulated for research precision. The intranasal delivery format is purpose-built to support investigational models requiring efficient peptide delivery without the complexity of injectable preparation.
• Secure, reliable fulfillment. We ship nationwide and internationally with a payment system that protects your personal and financial information from unauthorized access.
• Researchers trust Behemoth Labz because we hold our products to the same standards you hold your experiments — no shortcuts, no compromises.

Research Applications

• Energy and Metabolic Signaling — MOTS-C activates AMPK, supporting research into cellular energy regulation in preclinical models.^[3]
• Gene Expression Modulation — Nuclear translocation of MOTS-C allows researchers to study transcriptional programs linked to metabolic adaptation.^[4]
• Metabolic Pathway Research — Used in laboratory studies examining glucose and lipid utilization under controlled metabolic challenges.^[5]
• Cellular Adaptation Studies — Enables mechanistic investigation of how cells respond to energy stress at a molecular level.^[6]
• AMPK Pathway Investigation — Serves as a research tool for studying AMPK-mediated signaling and adaptive energy regulation in preclinical models.^[7]

References

1. Basu, U., et al. (2020). Structure, mechanism, and regulation of mitochondrial DNA transcription initiation. Journal of Biological Chemistry, 295(52), 18406–18425.
2. Tang, M., et al. (2023). The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury. Scientific Reports, 13(1).
3. Yuan, Y., et al. (2023). The role of AMPK signaling in ulcerative colitis. Drug Design Development and Therapy, 17, 3855–3875.
4. González-Arzola, K., & Díaz-Quintana, A. (2023). Mitochondrial factors in the cell nucleus. International Journal of Molecular Sciences, 24(17), 13656.
5. Wang, P., et al. (2025). Mediation of fasting blood glucose between relative muscle strength and hypertension. Diabetology & Metabolic Syndrome, 17(1), 372.
6. Frańczak, M., et al. (2026). Mitochondria as a therapeutic target in neurodegeneration caused by hypoxia and ischemia. Pharmacological Reports, 78(1), 1–26.
7. Xia, W., et al. (2023). Role of anthraquinones in combating insulin resistance. Frontiers in Pharmacology, 14.

Disclaimer: This product is intended strictly for laboratory and experimental use. Not for human or animal consumption. All products sold by Behemoth Labz are for research purposes only.