ARA-290

Product Details: ARA-290 Peptide

ARA-290 is a synthetic peptide derived from the B-domain of erythropoietin (EPO), designed exclusively for laboratory and research applications. It is supplied as a high-purity, stable powder, soluble in aqueous solutions, enabling reproducible in vitro and ex vivo studies [1].

Mechanism of Action

ARA-290 selectively binds the tissue-protective receptor (TPR), a heteromer of the EPO receptor (EPOR) and beta common receptor (βcR), activating cytoprotective signaling pathways without stimulating erythropoiesis [3].

Activation of TPR by ARA-290 modulates JAK/STAT and PI3K/Akt pathways, which promote cell survival, anti-inflammatory responses, and protection against oxidative stress [4]. Its selective mechanism allows studies of tissue protection independently of red blood cell production [3].

Properties of ARA-290 Peptide:

• Molecular Formula: C₅₁H₈₄N₁₆O₁₆  
• Molecular Weight: 1249.4 g/mol  
• CAS Number: 925963-34-3  
• PubChem CID: 91810664  
• Synonyms: ARA-290; Cibinetide; EPO-derived tissue-protective peptide  

Research Applications/Benefits of ARA-290 Peptide:

• Study tissue-protective signaling pathways in vitro [5].
• Investigate anti-inflammatory and cytoprotective mechanisms [6].
• Examine oxidative stress modulation and cell survival [7].
• Model non-erythropoietic effects of EPO-derived peptides [8].

Why Choose BehemothLabz for ARA-290 Peptide?

Choose BehemothLabz, choose quality! We are among the few online sellers that believe in the integrity and purity of products. Our ARA-290 Peptide is designed to meet the industrial criteria and the needs of researchers.Before launching our products, we test them through an independent laboratory to check their purity and ingredients. This procedure maximizes the accuracy and findings of your research experiments.  

Additionally, we deliver nationwide and internationally. We use a secure payment system that safeguards your personal information and prevents unauthorized third-party access.So, purchase ARA-290 Peptide Liquid now and experience quality and purity for your research.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments. 

References

1. Brines, M. L., & Cerami, A. (2005). Emerging biological roles for erythropoietin in tissue protection. Nature Reviews Neuroscience, 6(6), 484–494. 
2. PubChem. “ARA-290.” National Center for Biotechnology Information. 
3. Brines, M. L., & Cerami, A. (2008). A novel tissue-protective peptide from erythropoietin. Trends in Pharmacological Sciences, 29(2), 73–78. 
4. Leist, M., Ghezzi, P., Grasso, G., et al. (2004). Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science, 305(5681), 239–242. 
5. Brines, M., et al. (2015). Cibinetide (ARA 290) and tissue protection: experimental and clinical studies. Expert Opinion on Investigational Drugs, 24(8), 1051–1060. 
6. Brown, R., et al. (2011). Anti-inflammatory effects of the EPO-derived peptide ARA 290. Journal of Molecular Medicine, 89, 563–571. 
7. Leist, M., et al. (2004). Protective effects of non-erythropoietic EPO derivatives against oxidative stress. Science, 305(5681), 239–242. 
8. Brines, M., & Cerami, A. (2012). Non-erythropoietic effects of EPO derivatives: experimental models. Trends in Pharmacological Sciences, 33(7), 317–325.