Cardiogen

Buy Cardiogen Peptide (20mg) Online | BehemothLabz

Cardiogen is a synthetic tetrapeptide bioregulator. Researchers also refer to it by its amino acid sequence, AEDR, or its full chemical name, H-Ala-Glu-Asp-Arg-OH. It belongs to a family of short organ-specific peptides developed by the research group of Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. This family of peptides was designed by analyzing amino acid compositions of tissue-specific peptide extracts and synthesizing the shortest active sequences capable of interacting with gene regulatory machinery in target tissues.

So, why do researchers find Cardiogen particularly useful? Because of its cardiac tissue specificity. In preclinical models, Cardiogen has been investigated for its ability to interact with chromatin-associated regulatory elements in cardiac-derived cells and to modulate gene expression patterns relevant to cardiomyocyte proliferation and apoptosis signaling. It is a low-molecular-weight, water-soluble peptide that serves as an accessible experimental probe in cardiovascular aging and cell biology research.

ATTENTION: This product is strictly for LABORATORY AND RESEARCH PURPOSES ONLY. Not for human or veterinary use.

Mechanism of Action of Cardiogen (AEDR)

How Does Cardiogen Interact with Gene Regulatory Machinery?

Cardiogen is thought to interact with chromatin-associated elements in cardiac cell nuclei in experimental settings. According to the peptide bioregulator framework proposed by Khavinson et al., short peptides of two to seven amino acid residues are capable of penetrating cell nuclei, interacting with nucleosomes and histone proteins, and influencing both single-stranded and double-stranded DNA in a sequence-specific manner. For Cardiogen, this interaction is hypothesized to modulate the transcriptional accessibility of genes encoding cytoskeletal and nuclear matrix proteins in cardiomyocytes. These mechanistic proposals are based on in vitro and preclinical animal studies and have not been validated in controlled human research.

Cardiomyocyte Proliferation and Apoptosis Signaling

In experimental cardiac tissue culture models, Cardiogen has been observed to influence markers of cardiomyocyte proliferation while simultaneously suppressing apoptosis-associated protein expression, including p53. These observations were noted in both young and aged rat myocardial tissue cultures, with the peptide maintaining activity across both age groups — a characteristic not observed with individual amino acids tested under the same conditions. These are in vitro tissue culture findings only.

Properties of Cardiogen (AEDR)

Research Findings on Cardiogen (AEDR)

Research has examined the role of short peptides, including Cardiogen, in the regulation of gene expression in cardiovascular cell systems. A systematic review by Khavinson et al. examined the capacity of short peptides consisting of two to seven amino acid residues to penetrate cell nuclei and interact with chromatin, histone proteins, and DNA in a sequence-specific manner. This review established the mechanistic framework within which Cardiogen’s proposed cardiac gene regulatory activity is investigated. 

The authors noted that DNA-peptide interactions relevant to gene promoter recognition are important for transcription and replication in experimental systems. This systematic review covers the broader class of short bioregulator peptides. Cardiogen (AEDR) is referenced within this class framework. Findings apply to the short peptide bioregulator class and should not be interpreted as compound-specific evidence for AEDR alone. [Khavinson et al., 2021].

Further investigation has specifically examined the AEDR tetrapeptide in the context of cardiovascular senescence and age-associated inflammatory signaling. Research identified that AEDR, alongside related short peptides, may regulate the synthesis of molecules involved in the senescence-associated secretory phenotype (SASP) and inflammaging processes in cardiovascular cell populations. 

The study noted interactions with cytokine expression networks, including IL-1, IL-6, TNFα, and NF-κB signaling pathways in preclinical cell models. This finding is associative and is derived from a class-level investigation of short peptide bioregulators and is not from a compound-specific interventional study on AEDR alone. These findings are preliminary, and data remain limited without compound-specific validation. [Khavinson et al., 2023].

Note: Cardiogen is not approved by the FDA for any use. It is intended strictly for laboratory research purposes only and is not for human consumption.

Risk and Handling Information

Risk Tier: LOW TO MODERATE

Cardiogen is a short tetrapeptide composed entirely of naturally occurring amino acids. Its acute toxicological profile in humans has not been formally established. While its natural amino acid composition suggests a low immunogenic potential, this cannot be confirmed without a formal toxicological assessment. All handling must be conducted under appropriate laboratory safety conditions.

Exposure Risk

Lyophilized powder presents an inhalation hazard during weighing and reconstitution. These procedures must be performed inside a certified fume hood. N95 respiratory protection is recommended as a minimum. Nitrile gloves, a lab coat, and safety eyewear must be worn during all handling steps. Avoid direct skin and eye contact with both the powder and the reconstituted solution.

Toxicity Uncertainty

No acute or chronic toxicity data exist for Cardiogen in human subjects. The absence of known toxicity should not be interpreted as confirmed safety. Any uncontrolled human exposure must be documented and managed per institutional first-aid and incident reporting protocols.

Storage Risk

Store lyophilized material at −20°C in sealed vials, protected from light and moisture. Reconstituted solution must be used within 7 days and kept at 4°C. Repeated freeze-thaw cycling must be avoided. Single-use aliquoting is recommended before initial reconstitution.

Disposal

All residual material, vials, and contaminated consumables must be disposed of in full compliance with institutional biosafety regulations and applicable chemical waste management protocols.

Why Choose BehemothLabz to Buy Cardiogen Peptide?

Behemoth Labz supplies Cardiogen (AEDR) for laboratory and research use only. Each batch undergoes independent third-party HPLC analysis. A Certificate of Analysis is available for every production lot. BehemothLabz does not self-certify purity, and external laboratories verify each lot before release.

Disclaimer

Please make sure you go through the Terms and Conditions and familiarize yourself with them, as it is important. Please research the scientific uses of this product before making any purchases. Make note that the packaging and labels of the product may differ from those shown on the website. All research involving this compound must comply with IRB guidelines for clinical investigations and IACUC directives for animal studies under the Animal Welfare Act (AWA).

Buying the product means you agree to our Terms and Conditions. You can contact our customer service team at support@behemothlabz.com if you are not fully satisfied with the product.

ATTENTION: All BehemothLabz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

Reference Links

Khavinson, V. K., Popovich, I. G., Linkova, N. S., Mironova, E. S., & Ilina, A. R. (2021). Peptide regulation of gene expression: A systematic review. Molecules, 26(22), 7053. https://pubmed.ncbi.nlm.nih.gov/34834147/

Khavinson, V., Linkova, N., Dyatlova, A., Kantemirova, R., & Kozlov, K. (2023). Senescence-associated secretory phenotype of cardiovascular system cells and inflammaging: Perspectives of peptide regulation. Cells, 12(1), 106. https://pubmed.ncbi.nlm.nih.gov/36611900/